GC-MS

Biology / Life Science

Metabolomics is a vital branch of the "omics" sciences, offering deep insights into biochemical processes. While LC/MS (/MS) is widely used, the GC/MS approach provides a unique advantage: once metabolites are properly derivatized, GC/MS enables the detection of a vast array of metabolite types in a single analysis.
The AccuTOF™ GC-Alpha GC - high mass-resolution TOFMS and the msFineAnalysis AI Ver. 3 software, equipped with a comprehensive AI-predicted EI mass spectral library of 200 million compounds (including 75 million in-silico generated metabolite derivatives), empower researchers to identify previously unknown metabolites with precision and efficiency.

Qualitative and Quantitative Analysis of Organic Acids in Urine by Gas Chromatography-High Resolution Mass Spectrometry with Hard Ionization and Soft Ionization

Non-Targeted Analysis of Metabolites in Sake by using Gas Chromatograph - Time-of-Flight Mass Spectrometer (GC-TOFMS)

Plastics / Polymer

Accurate characterization of polymeric materials—including virgin, degraded, and recycled forms—is essential for advancing a sustainable circular economy.
These application notes highlight advanced analytical techniques for investigating complex polymers using pyrolysis GC-MS combined with AI-enhanced structural analysis. Readers will discover how cutting-edge mass spectrometry, supported by in silico spectral libraries and deep learning algorithms, enables precise identification of polymer pyrolyzates, additives, and degradation products.
The studies presented offer practical workflows that enhance material analysis, driving innovation in polymer development, quality assurance, and failure diagnostics.

Structure Analysis of Polymer Pyrolyzate by Pyrolysis GC-TOFMS and AI -A Case Study of AI Library Containing in silico Pyrolyzate

Analysis of recycled PET products by Pyrolysis-GC-TOFMS

Analysis of Polyethyleneimine using Field Desorption (FD) of GC-TOFMS

Analysis Example：Rapid Analysis of Polymer additives

Chemistry

Structural confirmation of newly synthesized compounds is essential for successful publication, while elucidation of unexpected byproducts is critical for optimizing synthetic pathways.
These application notes showcase the integration of high-resolution mass spectrometry, AI-assisted analysis, and NMR spectroscopy for precise structural elucidation of organic compounds.
Organic chemistry professionals will gain valuable insights into advanced workflows for verifying complex molecular structures—particularly those with high boiling points or intricate architectures—using direct MS probe techniques and predictive software tools.

Structure Verification of a Synthetic Organic Compound Using Data from Gas Chromatography-High Resolution Mass Spectrometry and Nuclear Magnetic Resonance - Direct Probe Measurement

Structure Verification of a Synthetic Organic Compound Using Data from Gas Chromatography-High Resolution Mass Spectrometry and Nuclear Magnetic Resonance - EI/FI Measurement

Food / Plant

Flavor compounds play a critical role in determining the quality and consumer appeal of food products.
These application notes highlight advanced GC-MS techniques for analyzing flavor, aroma, and other quality-related compounds in complex food matrices. By combining electron and soft ionization methods with AI-powered msFineAnalysis software, these studies demonstrate accurate identification of volatile and semi-volatile compounds.
Food industry professionals will gain valuable insights into enhancing product quality, detecting off-flavors, and verifying authenticity through high-resolution, automated mass spectrometric analysis.

Structure analysis of unknown compound in oyster using HS-SPME-GC-TOFMS

Analysis of the aroma components of spearmint essential oil by GC-TOFMS and AI structure analysis

Comparison of aromatic compounds in two different red wines by using GC-High resolution TOFMS with the integrated data analysis of msFineAnalysis AI

Qualitative Analysis of Peach Juice by using HS-SPME-GC-QMS

Environment

High sensitivity and specificity are essential for accurate environmental analysis using GC-MS. While helium has long been the preferred carrier gas for achieving optimal chromatographic separation and sensitivity, its rising cost and unstable supply have prompted the need for alternatives. The following application notes showcase the unique capabilities of JEOL's GC-Quadrupole MS system, which delivers the high sensitivity required for environmental analysis using nitrogen—a safe, cost-effective, and readily available substitute for helium.

Analysis of Pesticides Using Low-Pressure GC-MS with Nitrogen Carrier Gas

Analysis of volatile organic compounds (VOCs) in water by HS-GC-MS Method

Energy

Advancing sustainable energy solutions requires both the optimization of energy storage systems—such as liquid and solid-state lithium-ion batteries—and the precise characterization of hydrocarbons in complex mixtures like crude oil and pyrolysis oil derived from recycled plastics. The following application notes demonstrate how JEOL's advanced GC-MS technologies contribute to these efforts, offering powerful analytical capabilities for both energy storage and resource recovery.

Analysis of gases generated from all solid-state Li-ion batteries using sulfide-based solid electrolytes

Analysis of Contaminants in Low Viscosity Solvents for Electrolytes in Liquid-LIB by GC-TOFMS

Rapid analysis of pyrolysis oil using blank tube-FI method and GC-EI/FI method of GC-TOFMS

Multifaceted crude oil analysis using GC-EI/FI, blank tube-FI, and FD on GC-TOFMS

Semiconductor

Quality of reagents used in semiconductor fabrication is critical for ensuring product yield and device reliability. Even trace impurities in cleaning solvents can compromise wafer performance and lead to costly defects.
This application note introduces advanced analytical techniques for detecting and identifying impurities in high-purity reagents, demonstrating how high-resolution mass spectrometry combined with AI-assisted analysis supports cleaner, more reliable semiconductor manufacturing.

Qualitative Analysis of Impurities in a Solvent for Semiconductor Fabrication using msFineAnalysis AI

Petroleum and Petrochemical

Detailed characterization of hydrocarbons is critical for both conventional petroleum crude oil and sustainable alternatives derived from recycled plastics and biomass. The JMS-T2000GC AccuTOF™ GC-Alpha offers a comprehensive suite of capabilities to meet these analytical demands, including high mass resolution, Field Ionization (FI)—a unique soft ionization technique ideal for hydrocarbon analysis—and msRepeatFinder, a powerful software tool for group-type analysis of hydrocarbons. Together, these features enable precise and insightful analysis across a wide range of complex hydrocarbon matrices.

Petroleum and Petrochemical Solutions with GC-TOFMS