Quantitative NMR (qNMR)
Moving into the future with an evolution of reliability
Quantitative analysis is essential to our daily lives, supporting activities like health checks, content labeling for foods and pharmaceutical products, and the monitoring of harmful substances. Quantitative NMR (qNMR) has recently been a focus of attention as an even more reliable method of performing quantitative analysis. In order to increase the reliability of quantitative analysis and contribute to the realization of a safe and secure society, JEOL has been involved in the standardization of the qNMR method as a general analysis method that can be used by anyone anywhere, in addition to developing instruments and software and proposing comprehensive analytical support, JIS and ISO standardization was achieved.
We continue to propose practical tools and support for the qNMR method, from sample preparation to analysis, making use of the know-how gained from our past efforts.
What is qNMR ?
Quantitative NMR or qNMR is quantitative analysis using NMR.
The principle difference from other quantitative analytical methods is absolute quantitative analysis method which does not require the same standard substance as an analyte.
Quick Introduction to Quantitative NMR
Topics
ISO standardization of qNMR (quantitative NMR) methods
An international standard for the quantitative purity determination of organic compounds using nuclear magnetic resonance (NMR) has now been adopted by ISO 24583, Quantitative nuclear magnetic resonance spectroscopy - Purity determination of organic compounds used for foods and food products -General requirements for 1H NMR internal reference methods. magnetic resonance spectroscopy - Purity determination of organic compounds used for foods and food products -General requirements for 1H NMR internal standard method ).
The qNMR (quantitative NMR) method is an analysis method that enhances reliability. This international standard defines the measurement procedures for the qNMR method, which is a "quantitative analysis" method using NMR, and improves the reliability of the purity determination of organic compounds around the world. This will further promote the implementation of the qNMR method in society and contribute to the realization of a comfortable, safe and secure society.
The international standard was published by ISO on 19 December 2022.
Committee for the Development of qNMR Technology in Japan / qNMR-J
Committee for the Development of qNMR Technology in Japan was established on October 31, 2018. The aim is to be the basis for activities of progress and dissemination. Currently, the focus is on activities by working groups promoting international standardization, but in the future, we aim to be a participatory meeting in which a wide and open exchange can be active. The purpose of establishment details can be confirmed here. We keep posting our activities such as the schedule on our website.
News
Relevant sites
Standards for qNMR: FUJIFILM Wako Pure Chemical Corporation
ISRD (qNMR Internal Standard Reference Data):BIPM
BIPM (International Bureau of Metrology) is conducting research on analytical methods of standard substances using qNMR. ISRD of maleic acid has been released as information on reference standard for qNMR.
Evaluation of physical properties for use as a reference standard for qNMR is gathered and it is information necessary for selection of reference standard. This information is scheduled to be released on BIPM's HP, and it will be useful for selection of reference standard to implement qNMR.
JAPANESE STANDARDS ASSOCIATION
JIS K 0138 : General rules for qNMR
ISO 24583 : General requirements for 1H NMR internal standard method
Events
Products
Nuclear Magnetic Resonance Spectrometer (NMR)
Automated qNMR analysis(SMILEQ)
https://www.jeoljason.com/softwares-nmr-laboratories-smileq/qNMR analysis software(JASON / SMILEQ plugin) YouTube
https://youtu.be/ZDecamUawH4 https://youtu.be/qrk803hcQJw
https://youtu.be/kjRLq-eO8Lw
SMILEQ(Spectral Management Interface Launching Engine for Q-NMR)
JASON (JEOL Analytical Software Network)
Application note
What is qNMR (quantitative NMR) ?
Application of qNMR Part1: Quality control of organophoshorus pesticides
Application of qNMR Part2: Quantification of carminic acid in cochineal extract
Application of qNMR Part3: Quantification of quercetin in Tartary buckwheat
Application of PULCON to purity assay of Acetoaminophen
System validation in Quantitative NMR
Delta NMR software for quantitative NMR analysis
