MALDI-TOFMS
Matrix-assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometer (MALDI-TOFMS) has been used in the biochemistry field for polymer compounds such as protein. However, the applications are expanding now because of the high mass resolving power of MALDI-TOFMS. They include evaluation of complex polymer material such as synthetic polymer, analysis of low molecular compounds such as medical products, and mass imaging which is to visualize the distribution of target compounds.
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MALDI-TOFMS Product List
JMS-S3000 SpiralTOF™-plus 3.0Matrix-Assisted Laser Desorption/Ionization Time-of-FlightMass Spectrometer
The JMS-S3000 SpiralTOF™-plus 3.0 is a MALDI-TOFMS* that uses innovative SpiralTOF ion optics that has been updated to extend the mass range of this high resolution system. The JMS-S3000 defines a new standard in MALDI-TOFMS performance and provides state-of-the-art analytical solutions for a wide range of research areas such as functional synthetic polymers, materials science, and biomolecules.
JMS-S3000 SpiralTOF™-plus 3.0 Polymer Analysis System
The combination of the JMS-S3000 SpiralTOF™-plus 3.0's high mass resolution, high mass accuracy, and wide dynamic range with the msRepeatFinder polymer analysis software makes it the most powerful polymer analysis system.
JMS-S3000 SpiralTOF™-plus 3.0 Mass Spectrometry Imaging System
MALDI MS imaging was initially developed to focus on high molecular weight compounds such as proteins and peptides. However, with the expanding applications of MALDI MS imaging, the interests have shifted to include smaller molecules such as lipids, pharmaceuticals, and pharmaceutical metabolites. Conventional MALDI-reflectron TOFMS has difficulty discerning small molecule signals from matrix molecules. In the case of MALDI MS imaging, signals from unwanted molecules on the specimen surface will often interfere with signals from the target analytes. High selectivity by means of high mass-resolving power is essential for obtaining reliable target analyte spatial distributions. The SpiralTOF™-plus 3.0 with its high mass-resolving power is indispensable for MALDI MS imaging.
MALDI-TOFMS Applications
Biology / Life Science
MALDI-TOFMS is highly effective for analyzing biomolecules due to its soft ionization and high sensitivity. It enables rapid, accurate profiling of proteins, peptides, and glycans, facilitating biomarker discovery in clinical research. Minimal sample preparation and high throughput make it ideal for diagnostics and disease-related studies.
Plastics / Polymer
MALDI-TOFMS enables detailed characterization of synthetic polymers, including molecular weight distribution, end-group analysis, and copolymer composition. Its high sensitivity and soft ionization allow intact analysis of large macromolecules with minimal fragmentation, supporting research, quality control, and structural elucidation in polymer science and material development.
End-group analysis of high dispersity synthetic polymers using SEC-MALDI
Structural analysis of a binary copolymer and a quaternary copolymer polyester
Structural analysis of UV-degraded polyethylene terephthalate
Chemistry
MALDI-TOFMS offers fast and accurate analysis for a wide range of organic synthetic compounds from low-molecular-weight to high-molecular-weight molecules. Its soft ionization preserves structural integrity, enabling precise molecular weight determination and impurity detection. Minimal sample preparation and high sensitivity make it ideal for synthetic chemistry and compound verification.
Accurate mass analysis of Boroxine cage, a molecular weight of about 10,000
Accurate mass analysis of medicinal properties in a combination cold remedy
Structure analysis of a photodegradation product of reserpine
Food / Plant
MALDI-TOFMS enables rapid and sensitive analysis of food and plant samples, identifying compounds such as peptides, lipids, and sugars. Its soft ionization preserves molecular structures, making it ideal for profiling components contained in food. It supports quality control, authenticity testing, and nutritional or functional ingredient studies.
Molecular Structure Analysis of Alkaloids
MALDI-TOFMS Usage Example（Past Webinars）
A New Proposal for Copolymer Analysis -Multifaceted Analysis by High-Resolution Mass Spectrometry and NMR-
Many synthetic polymeric materials utilize copolymers composed of two or more monomers. Because their structures are more complex than homopolymers, the information that can be obtained with a single analytical instrument is limited. In this seminar, we will introduce comprehensive structural analysis methods that utilize information obtained from various methods such as NMR, GC-TOFMS, MALDI-TOFMS, and TDP-DART-TOFMS.
MALDI-TOFMS News Release
Interview “I want to make a polymer visible”
INTERVIEW
I want to make a polymer visible
Hiroaki Sato: Ph.D.
Deputy Director, Research Institute for Sustainable Chemistry, National Institute of Advanced Industrial Science and Technology (AIST)
Dr. Sato has been closely accompanying the evolution of mass spectrometers for 30 years. By fully utilizing the state-of-the-art mass spectrometers, he has been clarifying what is happening in the world of polymers. The evaluation methods with his knowledge are about to give new strength to the chemical industry.
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