The ROYALPROBE™ HFX is the world’s first liquid NMR probe switchable between single tune and dual tune mode on the High Frequency coil without compromising the NMR performance. The ROYALPROBE™ HFX operating in single tune mode has the performance for sensitivity and pulse width as the standard ROYALPROBE™. Operating the ROYALPROBE™ HFX in dual tune mode allows for a wide variety 1H and 19F of advanced NMR experiments including 1H{19F}, 19F{1H}, 13C{1H,19F}, and many unique 13C{1H, 19F} correlation experiments to simplify spectral assignments of modern complex fluorine containing compounds for the pharmaceutical and polymer industries. The Low Frequency coil is not limited to 13C, but can be tuned to any nucleus between 31P and 15N with the same experimental flexibility as 13C experiments a feature unique to the ROYALPROBE™ HFX.
Features
The JEOL ROYALPROBE™ HFX is the world’s first liquid NMR probe switchable between single tune and dual tune mode on the High Frequency coil without compromising the NMR performance.* The ROYALPROBE™ HFX operating in single tune mode has the same sensitivity and pulse width performance as the standard ROYALPROBE™.
Two probes merged into one
The JEOL ROYALPROBE™ HFX
Application examples of ROYALPROBE HFX -1-
Operating the ROYALPROBE™ HFX in dual tune mode allows for a wide variety 1H and 19F of advanced NMR experiments including 1H{19F}, 19F{1H},13C{1H,19F}, and many unique 13C{1H, 19F} correlation experiments to simplify spectral assignments of modern complex fluorine containing compounds for the pharmaceutical and polymer industries.
19F -NMR examples measured on a standard two RF channel JNM-ECZ500R
25mg, 1,1,2,3,3,3-Hexafluoropropyl ethyl ether / CDCl3 13C-NMR 256scans
Application examples of ROYALPROBE™ HFX -2-
2D 1H-13C HSQC with 19F decoupling, collected on a JEOL JNM-ECZ500R with optional HF2 19F 3rd channel
CRISIS-HSQCAD, 25% NUS 4scans
1H-13C gHMBCAD, 19F Decoupling Simplifies Assignments, 25% NUS, 8 Scans
10mg Fluticasone Propionate / DMSO-d6
Application examples of ROYALPROBE HFX -3-
The Low Frequency coil is not limited to 13C, but can be tuned to any nucleus between 31P and 15N with the same experimental flexibility as 13C experiments a feature unique to the ROYALPROBE™ HFX.
10mg, Decafluorotriphenyl Phosphine / CDCl3collected on a JEOL JNM-ECZ500R with optional HF2 19F 3rd channel
25mg 2,3-difluoro-5-(trifluoromethyl)pyridine /Benzene-d6 1H-15N HMBC 4scans
Application
Application ROYALPROBE_HFX
Application for fluorine compounds
14N decoupled 1H–19F HOESY with ROYALPROBE™ HFX
Application of 14N decoupled HETCOR for 19F-mediated amide hydrogen bonds with ROYALPROBE™ HFX
ROYALprobe™ HFX for 700MHz console is newly released
Application of HFX NMR to Facilitate the Complete Assignment of the Anti-fungal Agent Voriconazole
Determine number of fluorines attached to each carbon by 13C NMR spectroscopy!
Structure Elucidation of Fluorinated Compounds by NMR
ROYALPROBE™ HFX Application Example (2)
ROYALPROBE™ HFX Application Example (1)
More Info
Are you a medical professional or personnel engaged in medical care?
No
Please be reminded that these pages are not intended to provide the general public with information about the products.