Determine number of protons attached to each carbon in fluorine-containing compounds by ¹³C NMR spectroscopy!

We usually use DEPT135 (Distortionless Enhancement by Polarization Transfer) experiment to analyze ¹³C multiplicity. In the case of fluorine-containing compounds, not only ¹H decoupling but also ¹⁹F decoupling is efficient. J_CF are larger than J_CH, and so ¹³C peaks are often affected even by long-range couplings. In such instances, we can achieve the maximum sensitivity and singlet signals by ¹³C measurement with simultaneous ¹H and ¹⁹F decoupling. The figures below show ¹³C and DEPT spectra of 20% 2,2,3,3-tetrafluoropropanol in CDCl₃. You can see that ¹³C and DEPT spectra are simplified with ¹⁹F decoupling.

ROYALPROBE HFX can perform these ¹H, ¹⁹F, ¹³C triple-resonance measurement, even with a standard 2-channel console!

¹³C{¹H｝ and ¹³C{¹H, ¹⁹F} spectra, 64 scans

DEPT and DEPT {¹⁹F} spectra, 32 scans

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