No-D NMR as low-cost and high-throughput measurements
NM060023E
No-D NMR is a technique for measuring NMR signals of organic compounds without deuterated solvents but with normal solvents.
No-D NMR does not require deuterated solvents and so can save costs. Also, the process of dissolving samples in deuterated solvents is omitted, or reaction solution or distillation solution can be measured, as it is, in no-D NMR. Thereby, it can save total experimental time and can be applied to the samples unstable in preparation.
- 1.Resolution adjustments by 1H-selective FG shimming for normal solvent signals.
- 2.Automatic detection and suppression of normal solvent signals.
- 3.Automatic referencing using normal solvent signals.
* NMR lock is not executed.
Resolution adjustment, solvent peak suppression, and reference setting are automatically executed.
Results from “1D 2D suite no d”
Resolution adjustment by 1H-selective FG shimming
Resolution can be adjusted by FG shimming for a selected 1H signal of the sample, such as a normal solvent signal. The result of 1H-selective FG shimming is shown below.
Automatic detection and suppression of a normal solvent signal
An automatic measurement of no-D NMR executes a scout scan to find a solvent signal to be suppressed.
WET solvent suppression is performed by setting a solvent peak position detected automatically (left).
WET can suppress 13 C satellites as well as a main peak (right).
Note -
When solvent peaks are suppressed in no-D NMR, overlapped or adjacent peaks may be lost or reduced. In such cases, solvents should be chosen properly.Reference
No-D NMR Spectroscopy: A Simple Yet Powerful Method for Analyzing Reaction and Reagent Solutions Thomas R.Hoye, Brian M.Eklow,Troy D. Ryba, Mikhail Voloshin, and Letitia J.Yao Org.Lett.,6.953-956 2004Related Products
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