JMS-S3000 SpiralTOF™ series Life Science Applications Notebook

This is a compendium of life science related applications notes, JEOL News articles, and scientific journal articles based on the data acquired on JEOL ultra-high mass-resolution MALDI-TOFMS JMS-S3000 SpiralTOF™ series.

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Table of Contents

Mass Spectrometry Imaging　P1〜

• Phase analysis of mass spectrometry imaging data using high-resolution MALDI-TOFMS “NewSpiralTOF™” and vertex component analysis (MSTips No. 528)
• Mass image quality improvement using a machine learning model “FINE-AI Filter” (MSTips No. 526)
• Mass imaging of strawberry using the JMS-S3000 “SpiralTOF™-plus3.0” and transfer plate Poropare™ (MSTips No. 499)
• High Mass-Resolution MALDI-imaging MS for Drug Metabolism in Tissue Using the JMS-S3000 (MSTips No. 212)
• High Mass Resolution MALDI-imaging MS Using JMS-S3000 SpiralTOF™ and msMicroImager (MSTips No. 211)
• Fingerprint Analyses Using MALDI Imaging and SEM Imaging (MSTips No. 208)
• MALDI-Imaging MS of Lipids on Mouse Brain Tissue Sections Using Negative Ion Mode (MSTips No. 196)

Proteins and Peptides　P23〜

• High-Resolution Measurements of Proteins Using the Spiral Mode of JMS-S3000 “SpiralTOF™” (MSTips No. 297)
• MALDI-ISD Measurements Using Both the SpiralTOF™ Mode and the Linear Mode (MSTips No. 229)
• High Resolution and High Mass Accuracy MALDI-ISD Measurements (MSTips No. 228)
• High Sensitivity Analysis of Intact Proteins Using Linear TOF (MSTips No. 227)
• High Sensitivity Peptide Measurement with the New Matrix α-Cyano-4-Chlorocinnamic Acid
• Distinguishing Lysine and Glutamine in a Peptide
• Analysis of Phosphopeptide Using TOF-TOF (MSTips No. 184)
• Comparison of the JMS-S3000 SpiralTOF™-TOF and a 4-Sector Tandem Double-Focusing Mass Spectrometer (MSTips No. 181)
• Structural Analysis of a High Molecular Weight Peptide (MSTips No. 175)
• High-Energy CID Analysis of Bovine Serum Albumin (MSTips No. 174)
• Analysis of Bovine Serum Albumin (MSTips No. 166)

Lipids　P51〜

• Structural Analysis of Oxidized Triolein (MSTips No. 197)
• Structural analysis of phospholipids in egg yolk using JMS-S3000 “SpiralTOF™” with TOF-TOF option (MSTips No. 185)
• Structural Analysis of Triolein (MSTips No. 182)
• Structural Analysis of Tristearin (MSTips No. 178)
• Aglycon diversity of brain sterylglucosides: structure determination of cholesteryl- and sitosterylglucoside (Akiyama, H., et al., J. Lipid Res. 57, 2061-2072, 2016; open access article under the CC BY license)
• Structural Analysis of Triacylglycerols by Using a MALDI-TOF/TOF System with Monoisotopic Precursor Selection (Kubo, A., et al., J. Am. Soc. Mass Spectrom., 24, 684-689, 2013; open access article ©The Authors, 2012)

Oligosaccharides　P77〜

• Compositional and Structural Analysis of Labeled N-Linked Glycans Using JMS-S3000 NewSpiralTOF™ (MSTips No. 519)
• High-energy CID Mass Spectrometry of Oligosaccharides (MSTips No. 366)

Nucleic Acids　P83〜

• Analysis of oligonucleotides using JMS-S3000 "SpiralTOF™-plus 2.0" (MSTips No. 364)

Natural Products　P85〜

• Molecular Structure Analysis of Alkaloids (ED2022-05E)
• Analysis of the Natural Organic Compound SAAF by Using the TOF-TOF Option (MSTips No. 183)
• Analysis of the Natural Organic Compound YTX by Using the TOF-TOF Option

Drugs / Small Molecules　P91〜

• Amino Acid Composition and Structural Analysis of Dipeptides in Natto Using JMS-S3000 NewSpiralTOF™ (MSTips No. 521)
• Structural analysis of a small molecule using JMS-S3000 "SpiralTOF™-plus 2.0" ー MS/MS measurement of a photodegradation product of reserpine ー (MSTips No. 365)
• Analysis of a drug in urine by JMS-S3000 "SpiralTOF™" and TOF-TOF option (MSTips No. 263)
• Structural analysis of melatonin and related compounds using JMS-S3000 SpiralTOF™ with the TOF-TOF option (MSTips No. 256)
• Analysis of medicinal properties in a combination cold remedy by using JMS-S3000 “SpiralTOF™” (MSTips No. 241)
• High-Energy CID MS-MS Analysis of Small Organic Molecules (MSTips No. 173)
• MALDI for Small Molecule Analysis: A Complex Drug Mixture
• Accurate mass measurement of small organic molecules using JMS-S3000 “SpiralTOF™” (MSTips No. 168)

Details of the hardware and software　P111〜

• Mass Spectrometry Imaging using the JMS-S3000 “SpiralTOF™-plus” Matrix Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometer (Takaya Satoh, JEOL News, 55, 70-72, 2020)
• Development of JMS-S3000: MALDI-TOF/TOF Utilizing a Spiral Ion Trajectory (Takaya Satoh, JEOL News, 45, 34-37, 2010)
• The Relationship between Crystal Condition and Mass Resolving Power, Mass Accuracy (MSTips No. 206)
• High Mass Resolution MALDI-Imaging MS – High Stability of Peak Position during Imaging MS Measurement (MSTips No. 193)

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